AZN changes
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- Recent events
- Oct 30, 2026: AstraZeneca reported 9M and Q3 2026 results. Q3 Total Revenue was $16.2 billion, up 7% at constant exchange rates, and Q3 Core EPS was $2.79, up 19%. For the first nine months, Total Revenue was $46.9 billion, up 7%, and Core EPS was $8.00, up 14%. Oncology revenue rose 16% and Farxiga revenue fell 15% in the nine months. AstraZeneca kept its 2026 guidance and reported 12 positive Phase III readouts in 2026 to date. It will publish its FY 2026 results on February 9, 2027. Oct 30, 2026: AstraZeneca started the Reshaping for Sustainable Growth programme. It expects one-time restructuring costs of up to $2.0 billion and $1.5 billion of yearly pre-tax savings at the run rate, which it will put back into the pipeline. It expects to complete the programme by the end of 2029. Oct added: 27, 2026: Enhertu, which AstraZeneca shares with Daiichi Sankyo, was approved in the EU after surgery for patients with HER2-positive early breast cancer who still have invasive disease after treatment before surgery. In the DESTINY-Breast05 Phase III trial, Enhertu lowered the risk of invasive disease recurrence or death by 53% against T-DM1. It is the first EU approval of Enhertu in early breast cancer. Oct 22, 2026: The FDA gave accelerated approval to Ultomiris to reduce proteinuria in adults with primary IgA nephropathy at risk of disease progression. It is the first C5 complement inhibitor approved for this disease. In an interim analysis of the I CAN Phase III trial, Ultomiris reduced proteinuria by 43.4% against placebo at 34 weeks. Full approval depends on kidney function data from the same trial at week 106. Oct 11, 2026: The HICKORY Phase III trial of efzimfotase alfa in adolescents and adults with hypophosphatasia did not meet its main goal. The gain in the six-minute walk test was 17.05 metres against placebo, which was not statistically significant. AstraZeneca said that patients on placebo did better than expected, and it will continue to develop the drug. The FDA gave the drug Priority Review in September 2026. Oct 5, 2026: AstraZeneca completed a $2 billion equity investment in Summit Therapeutics. The two companies will test Summit's PD-1/VEGF antibody ivonescimab together with AstraZeneca's antibody drug conjugates, first in stomach and gut cancers. On October 2, AstraZeneca and Daiichi Sankyo also agreed to test Datroway with ivonescimab. Sep 14, 2026: The SERENA-4 Phase III trial of Etcamah (camizestrant) with palbociclib in first-line advanced ER-positive breast cancer did not meet its main goal of longer progression-free survival. Etcamah stays approved for patients with an ESR1 mutation, based on the SERENA-6 trial. Sep 8, 2026: AstraZeneca reported that Imfinzi with Imdelltra gave a statistically significant improvement in overall survival in small cell lung cancer. On September 7, the US approved Etcamah with a CDK4/6 inhibitor for first-line advanced breast cancer with an ESR1 mutation. Aug 25, 2026: AstraZeneca priced €2.55 billion of bonds in four parts, due from 2030 to 2038, with coupons from 3.402% to 4.169%. The bonds were issued on September 1, 2026. Aug 17, 2026: AstraZeneca stopped the eVOLVE-Lung02 Phase III trial of volrustomig with chemotherapy in first-line lung cancer, because the data monitoring committee said that it was unlikely to meet its main goals. On the same day, it reported positive Phase III results for Enhertu and for Tagrisso with Orpathys in lung cancer. Jul 27, 2026: AstraZeneca reported H1 2026 results. Total revenue was $30.7 billion, up 6% at constant exchange rates, and Core EPS was $5.21, up 11%. It kept its 2026 guidance and said that it is on track for its $80 billion revenue goal for 2030. It raised the interim dividend to $1.06 per share. Jul 9, 2026: The CARDIO-TTRansform Phase III trial of Wainua in transthyretin amyloid cardiomyopathy did not meet its main goal. The shares fell about 9% in early trading in London. On July 13, HSBC cut its rating to Hold.